The Factors That Effect The Direct Compression Of Microcrystaline Cellulose

THE FACTORS THAT EFFECT THE DIRECT COMPRESSION OF MICROCRYSTALLINE CELLULOSEA Literature ReviewSubmitted in partial fulfillmentof the requirements for the DegreeIntroductionTablet production by enjoin compression has steady increased over the years because it is an economic and a round-eyed procedure . Many graduate(prenominal) molecular weight polymers ar currently being utilize in pharmaceutical formulations as drug excipients . The processing variables and physical characteristics of the polymer excipient , granulating fluid , and drug used can determine the physical properties and rate of drug plough for the final preparation of these drug delivery systems . Currently , at that place is not a single excipient that meets all of the above mentioned requirements . most of the direct compression excipients commonly and widely used now are spray-dried lactose , anhydrous lactose , powderize cellulose , crystalline cellulose , dicalcium phosphate dihydrate tricalcium phosphate , direct compression stiffen , spray-crystallized dextrose /maltose , calcium sulphate dehydrate , Sorbitol and circumscribed rice starch (Alderbom and Nystrom 1996However , cellulose based materials , such as microcrystalline cellulose (MCC ) and powdered cellulose (PC , are among the most widely used direct compression excipients . Microcrystalline cellulose is perhaps the best filler- binder obtainable directly . MCC , despite being considered the best dry binder , it possesses unequal flow and disintegration properties and shows capping problems , especially when used in high amounts . Thus there is an enormous interest among pharmaceutical scientists relate in this area of research to either modify the real products or develop new materials with properties that satisfy as many an(prenominal) requirements as possible for direct compression (Swarbrick and Boylan 2002MCC was first introduced in 1964 under the brand name Avicel (R ) PH Currently , MCC is available from different vendors under different trade names . MCC is vigilant by hydrolysis of native a-cellulose , a fibrous semicrystalline material , with burn mineral acids . During hydrolysis the accessible amorphous regions are removed and a level-off degree of polymerization product is obtained .

MCC serves as an excellent binder and possesses high dilution potential . However , it suffers from high sensitivity to moisture and lubricants . Addition of a lubricant in the formulation is ask especially when high-speed tablet machine is used . MCC as well as shows poor flow and inconsistent disintegration properties (Swarbrick and Boylan 2002Microcrystalline Cellulose : and UsesCellulose is the most enormous natural polymeric raw material from which a procedure of excipients have been prepared . Cellulose is a major component of whole works materials , and has been an integral part of the man s diet throughout gay history . The name cellulose was coined by Payen who showed that the cell walls of all plants were constructed from cellulose (Nevell 1985 . Cellulose constitutes to a greater extent than 98 of cotton fibers , as much as 50 of wood fibers , and about 30 of cereal fibers Based on its nearly ubiquitous distribution in nature , and piece s long exposure to cellulose , cellulose and its derivatives are generally recognized as the safest and most acceptable polymer class for use in forage and pharmaceutical products (Nevell 1985Microcrystalline cellulose is purified cellulose . The empirical formula of MCC is (C12 H20 O10 )n . Its molecular weight...If you want to stick to a full essay, order it on our website: Orderessay

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