Dopamine

dopamine is a catecholamine neurotransmitter which is a chemical released by nerve center kiosks to send signals to other never jail cells, and plays an important role some(prenominal) central and peripheral awkward system. It helps control the brain to pay off hunting expedition and emotional responses. dopamine is made within dopamine neurons in the upper brainstem in the substantia Nigra. The site of movement of dopamine transmission affects nuclear number 18 shown in the fig. 1. This is the dopamine driveway: L-Tyrosine ? levodopa ? dopamine ? Norepinephrine ? Epinephrine Levodopa is born-again to dopamine by the spiel on of the enzyme dopa-decarboxylase in the brain dopamine is stored in and remains in axon terminals and released when the neuron is depolarised Dopamine interacts with specific membrane receptors to base up its effects, uses five cognize types of dopamine receptors, these receptors are denominate D1, D2, D3, D4, and D5 and they are G protein-coupled receptors. sense organ effects terminated by reuptake into the presynaptic neuron by a dopamine conveyer or by metabolous inactivation by monoamine oxidase B (MAO-B) or catechol-0-methyltransferase (COMT) Upon synthesis, dopamine is transported from the cell into synaptic vesicles by the vesicular monoamine transporter 2 (VMAT2).

Dopamine is stored in and remains in these vesicles until an action potential occurs and forces them to integrate with the cell membrane via a extremity known as exocytosis, thereby dumping dopamine into synapses. at once in the synapse, dopamine binds to and activates postsynaptic dopamine receptors, resulting in the signal of the presynaptic cell existence propagated to the postsynaptic neuron. Dopamine also binds to presynaptic dopamine receptors, which can both move the presynaptic cell or preclude it depending on their galvanizing potential. Presynaptic receptors with an restrictive potential are called autoreceptors and overcome neurotransmitter synthesis and release. They swear come forth to keep dopamine levels normalized in certain...If you want to get a full essay, order it on our website: Orderessay

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